主要な論文
  1.  Ozaki Y, Suzuki S, Kashiwase K, Shigenari A, Okudaira Y, Ito S, Masuya A, Azuma F, Yabe T, Morishima S, Mitsunaga S, Satake M, Ota M, Morishima Y, Kulski JK, Saito K, Inoko H, Shiina T: Cost-efficient multiplex PCR for routine genotyping of up to nine classical HLA loci in a single analytical run of multiple samples by next generation sequencing. BMC Genomics 2015 Apr 18; 16: 318. doi: 10.1186/s12864-015-1514-4, 2015.
  2.   Ozaki Y, Suzuki S, Shigenari A, Okudaira Y, Kikkawa E, Oka A, Ota M, Mitsunaga S, Kulski JK, Inoko H, Shiina T: HLA-DRB1, -DRB3, -DRB4 and -DRB5 genotyping at a super-high resolution level by long range PCR and high-throughput sequencing. Tissue Antigens 83: 10-16, 2014.
  3.  Shiina T, Suzuki S, Ozaki Y, Taira H, Kikkawa E, Shigenari A, Oka A, Umemura T, Joshita S, Takahashi O, Hayashi Y, Paumen M, Katsuyama Y, Mitsunaga S, Ota M, Kulski JK, Inoko H: Super high resolution for single molecule-sequence-based typing of classical HLA loci at the 8-digit level using next generation sequencers. Tissue Antigens 80: 305-316, 2012.
  4.  Mitsunaga S, Suzuki Y, Kuwana M, Sato S, Kaneko Y, Homma Y, Narita A, Kashiwase K, Okudaira Y, Inoue I, Kulski JK, Inoko H: Associations between six classical HLA loci and rheumatoid arthritis: a comprehensive analysis. Tissue Antigens 80: 16-25, 2012.
  5.  Ohtsuka M, Miura H, Nakaoka H, Kimura M, Sato M, Inoko H. Targeted transgenesis through pronuclear injection of improved vectors into in vitro fertilized eggs. Transgenic Res 21: 225-226, 2011.
  6.  Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T, Ito N, Kera J, Okada E, Yatsu K, Song YW, Lee EB, Kitaichi N, Namba K, Horie Y, Takeno M, Sugita S, Mochizuki M, Bahram S, Ishigatsubo Y, Inoko H: Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. Nature Genetics 42: 703-706, 2010.
  7.  Mano S, Endo TA, Oka A, Ozawa A, Gojobori T, Inoko H: Detecting linkage between a trait and a marker in a random mating population without pedigree record. PLoS ONE 4: e4956, 2009.
  8.  HUGO Pan-Asian SNP Consortium (Abdulla MA, Gojobori T, Inoko H, Lee S et al.): Mapping human genetic diversity in Asia. Science 326: 1541-1545, 2009.
  9.  Ota M, Fukushima H, Kulski JK, Inoko H: Single nucleotide polymorphism detection by polymerase chain reaction-restriction fragment length polymorphism. Nature Protoc 2: 2857-2864, 2007.
  10.  Bahram S, Inoko H: Microsatellite markers for genome-wide association studies. Nature Reviews Genetics 8: 164, 2007.
  11.  Tamiya G, Shinya M, Imanish T, Ikuta T, Makino S, Okamoto K, Furugaki K, Matsumoto T, Mano S, Ando S, Nozaki Y, Yukawa W, Nakashige R, Yamaguchi D, Ishibashi H, Yonekura M, Nakami Y, Takayama S, Endo T, Saruwatari T, Yagura M, Yoshikawa Y, Fujimoto K, Oka A, Chiku S, Linsen SEV, Giphart MJ, Kulski JK, Fukazawa T, Hashimoto H, M Kimura, Hoshina Y, Suzuki Y, Hotta T, Mochida J, Minezaki T, Komai K, Shiozawa S, Taniguchi A, Yamanaka H, Kamatani N, Gojobori T, Bahram S, Inoko H: Whole genome association study of rheumatoid arthritis Using 27,039 microsatellites. Hum Mol Genetics 14: 2305-2321, 2005.
  12.  International Chicken Genome Sequencing Consortium (Hillier LW, Fulton LA, Mardis ER, Wilson RK, Inoko H, Shiina T et al.): Sequence and comaprative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature 432: 695-716, 2004.
  13.  Shiina T, Shimizu S, Hosomichi K, Kohara S, Watanebe S, Hanzawa K, Beck S, Kulski JK, Inoko H: Comparative genome analysis of two avian (Quail and Chicken) MHC regions. J Immunol 172: 6751-6763, 2004.
  14.  Aanzai T, Kimura N, Yanagiya K, Kohara S, Shigenari A, Yamagata T, Kulski JK, Naruse TK, Fujimori Y, Fukuzumi Y, Yamazaki M, Tashiro H, Iwamoto C, Umehara Y, Imanishi T, Meyer A, Ikeo K, Gojobori T, Barham S, Inoko H: Sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence. Proc Natl Acad Sci USA 100: 7708-7713, 2003.
  15.  Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, Tamiya G, Kimura A, Bahram S, Inoko H: Identification of IkBL as the second Major Histocompatibility Complex-Linked susceptibility locus for rheumatoid arthritis. Am J Hum Genet 72: 303-312, 2003.
  16.  Kulski JK, Inoko H: MHC Genes. In the Encyclopedia of the Human Genome. Nature Publishing Group. Macmillan Publishers Ltd. Brunel Rd., Houndmills, Basingstoke, Hampshire, RG21 6XS, England, 2003.
  17.  Abi-Rached L, Gilles A, Shiina T, Pontarotti P, Inoko H: Evidence of en bloc duplication in vertebrate genomes. Nature Genetics 31: 100-105, 2002.
  18.  Suemizi H, Radosavljevic M, Kimura M, Sadahiro S, Yoshimura S, Bahrama S, Inoko H: A basolateral sorting motif in the MICA cytoplasmic tail. Proc Natl Acad Sci USA 99: 2971-2976, 2002.
  19.  Kulski JK, Shiina T, Anzai T, Kohara S, Inoko H: Comparative genomic analysis of the MHC: The evolution of class I duplication blocks, diversity and complexity from shark to man. Immunology Reviews 190: 95-122, 2002.
  20.  Shiina T, Ando A, Suto Y, Kasai, Shigenari A, Takishima N, Bahram S, Inoko H: Genomic anatomy of a premiar Major Histocompatibility Complex paralogous region on chrormosome 1q21-22. Genome Research 11: 789-802, 2001.
  21.  Ohtsuka M, Makino S, Yoda K, Wada H, Naruse K, Mitani H, Ozato K, Kimura M, Inoko H: Construction of a linkagemap of the medaka (Oryzias latipes) and mapping of the Da mutant defective in dorsal-ventral patterning. Genomic Research 9: 1277-1287, 1999.
  22.  Oka A, Tamiya G, Ota M, Kastuyama Y, Bahram S, Inoko H: Association analysis using refined microsatellite markers localizes a susceptible locus for psoriasi vulgaris within a 111 kb segment telomeric of the HLA-C gene. Hum Mol Genetics 8: 2165-2170, 1999.
  23.  Shiina T, Tamiya G, Oka A, Takishima N, Bahram S, Inoko H: Molecular dynamics of MHC genesis unraveled by sequencing analysis of the 1,796,938 bp HLA class I region. Proc Natl Acad Sci USA 96: 13282-13287, 1999.
  24.  The MHC sequencing consortium (Beck S, Gerahty D, Hood L, Inoko H): Complete structure and gene map of a human major histocompatibility complex (MHC). Nature 401: 921-923, 1999.
  25.  Ota M, Mizuki N, Katsuyama Y, Tamiya G, Shiina T, Oka A, Ando H, Yabuki K, Ohno S, Inoko H: The critical region for Behcet's disease in the human major histocompatibility complex is reduced to a 46 kb segment centromeric of HLA-B by association analysis using refined microsatellite mapping. Am J Hum Genet 64: 1406-1410, 1999.

当社でこれまでHLA検査依頼を受けた

検体のアリル頻度

クラスⅠ遺伝子クラスⅡ遺伝子

HLAハプロタイプの推定と頻度

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